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Evidence registry

Published drug–disease evidence records.

Each record includes graded evidence, PubMed and ClinicalTrials.gov citations, confidence scores, and human-reviewed AI summaries.

Metformin × Breast Cancer
Moderate Evidence

AMPK activation suppresses mTOR-mediated proliferation in breast epithelial cells.

2 PubMed1 trialsVerified June 28, 2026
Confidence score62%
Signal strength: LowLevel 2b–3 (observational + preclinical)
Sildenafil × Pulmonary Arterial Hypertension
Approved

PDE5 inhibition elevates pulmonary cGMP, reducing pulmonary vascular resistance.

1 PubMed1 trialsVerified June 25, 2026
Confidence score94%
Signal strength: HighLevel 1 (RCT + regulatory approval)
Thalidomide × Multiple Myeloma
Approved

Cereblon-dependent degradation of IKZF1/3 disrupts myeloma cell survival signaling.

2 PubMed1 trialsVerified June 20, 2026
Confidence score96%
Signal strength: HighLevel 1 (RCT + regulatory approval)
Dexamethasone × COVID-19
Strong Repurposing Signal

Glucocorticoid-mediated suppression of cytokine storm in severe COVID-19.

1 PubMed1 trialsVerified June 22, 2026
Confidence score91%
Signal strength: HighLevel 1 (large RCT)
Sirolimus (Rapamycin) × Tuberous Sclerosis Complex
Approved

mTOR inhibition reduces hamartoma growth in TSC1/TSC2-deficient cells.

1 PubMed1 trialsVerified June 18, 2026
Confidence score93%
Signal strength: HighLevel 1 (RCT + regulatory approval)
Levothyroxine (Synthroid) × Hypothyroidism
Approved

Exogenous T4 restores normal thyroid hormone levels and metabolic homeostasis.

1 PubMed0 trialsVerified July 1, 2026
Confidence score98%
Signal strength: HighLevel 1 (guideline-endorsed standard of care)
Aspirin × Cardiovascular Disease
Approved

Irreversible COX-1 inhibition reduces thromboxane A2-mediated platelet aggregation.

1 PubMed1 trialsVerified June 26, 2026
Confidence score92%
Signal strength: HighLevel 1 (meta-analysis of RCTs)
Finasteride × Benign Prostatic Hyperplasia
Approved

DHT reduction decreases prostate volume and improves urinary flow.

1 PubMed1 trialsVerified June 24, 2026
Confidence score95%
Signal strength: HighLevel 1 (RCT + regulatory approval)
Minoxidil × Androgenetic Alopecia
Approved

Topical minoxidil prolongs anagen phase; VEGF upregulation may promote follicular perfusion.

1 PubMed1 trialsVerified June 27, 2026
Confidence score88%
Signal strength: HighLevel 1 (RCT + regulatory approval)
Hydroxychloroquine × COVID-19
Insufficient Evidence

Proposed antiviral and immunomodulatory effects via lysosomal pH and autophagy.

1 PubMed2 trialsVerified June 29, 2026
Confidence score12%
Signal strength: Very LowLevel 1 (negative RCTs)