Target-centric intelligence
Follow perturbation profiles from target to therapy concept.
Each target profile links to modulating compounds and disease associations with graded evidence.
PRKAA1/2AMP-activated protein kinase
Moderate Evidence
Energy sensor kinase regulating metabolism and cell growth.
AMPK / mTOR crosstalk1 evidence records
Open target workspaceLaunch →MTORMechanistic target of rapamycin
Approved
Central kinase integrating nutrient and growth signals.
PI3K–AKT–mTOR1 evidence records
Open target workspaceLaunch →Enzyme degrading cGMP in smooth muscle.
NO–cGMP signaling1 evidence records
Open target workspaceLaunch →TNFTumor necrosis factor alpha
Pro-inflammatory cytokine central to immune activation.
TNF signaling0 evidence records
Open target workspaceLaunch →E3 ubiquitin ligase substrate receptor for IMiD immunomodulation.
Protein degradation / IMiD mechanism1 evidence records
Open target workspaceLaunch →NR3C1Glucocorticoid receptor
Strong Repurposing Signal
Nuclear receptor mediating corticosteroid anti-inflammatory effects.
HPA axis / inflammatory gene suppression1 evidence records
Open target workspaceLaunch →THRA/THRBThyroid hormone receptor
Approved
Nuclear receptors regulating metabolic gene transcription.
Thyroid hormone signaling1 evidence records
Open target workspaceLaunch →Enzyme in prostaglandin synthesis; platelet thromboxane production.
Arachidonic acid / eicosanoid1 evidence records
Open target workspaceLaunch →Inducible COX isoform in inflammation.
Arachidonic acid / eicosanoid0 evidence records
Open target workspaceLaunch →Converts testosterone to dihydrotestosterone.
Androgen metabolism1 evidence records
Open target workspaceLaunch →KCNJ11ATP-sensitive potassium channel
Approved
Regulates membrane potential in smooth muscle and β-cells.
Vascular tone / insulin secretion1 evidence records
Open target workspaceLaunch →Lysosomal pH and autophagy modulation.
Autophagy / antigen processing1 evidence records
Open target workspaceLaunch →